Preliminary communication

Drug-Induced Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopaty

Juraj Sepčić
Mira Bučuk
Olivio Perković
Dubravka Šepić-Grahovac
Biserka Trošelj-Vukić
Ivica Poljak
Marija Crnić-Martinović
Iztok Turel
Smiljana Ristić
Kristina Sepčić

Abstract

We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.

Keywords

ranitidine; ibuprofen; ciprofloxacin; drug interactions; aseptic meningitis; deafness

Hrčak ID:

59383

URI

https://hrcak.srce.hr/59383

Publication date:

1.10.2010.

Visits: 2.275 *