Acta clinica Croatica, Vol. 49 No. 2, 2010.
Professional paper
Functional Outcome after Thrombolytic Therapy
Siniša Miljković
Draško Prtina
Tamara Rabi Žikić
Zoran Vujković
Duško Račić
Vlado Đajić
Aleksandar Ješić
Milan Arbutina
Milorad Žikić
Abstract
In this paper, we report our experience from a prospective study in 40 ischemic stroke patients admitted during the last two years at University Department of Neurology Stroke Unit, Banja Luka Clinical Center, in order to assess the safety and efficacy of thrombolytic therapy, the impact of age, sex and risk factors, and functional outcome at 6 months of intravenous tissue plasminogen activator treatment. According to the National Institutes of Health Stroke Scale, there were 5 mild, 22 moderate and 13 severe stroke cases in the study group. The outcome measures at 6 months of thrombolytic treatment were taken in 38 (100%) patients, yielding a Functional Independent Measure score ≥90 (good clinical outcome) in 21 (52.50%) and modified Rankin Score ≤2 (good clinical outcome) in 22 (55%) patients. The rate of symptomatic intracerebral hemorrhage in tissue plasminogen activator treated patients was 5%, with a mortality rate of 17.50%. The outcomes were comparable with those found in the NINDS t-PA trial. Current guidelines recommend a ‘door-to needle’ time of less than 60 minutes and emphasize that ‘time is brain’.
Keywords
Brain ischemia – diagnosis; Brain ischemia – drug therapy; Stroke – diagnosis; Stroke – drug therapy; Fibrinolytic agents – therapeutic use; Thrombolytic therapy – time factors
Hrčak ID:
59935
URI
Publication date:
1.6.2010.
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