Original scientific paper
BASAL ANTRAL FOLLICLE COUNTS BY TRANSVAGINAL ULTRASONOGRAPHY FOR THE PREDICTION OF OVARIAN RESPONSIVENESS AND PREGNANCY RATES IN IVF/ICSI TREATMENT CYCLES
Mitko J Ivanovski
; Special hospital for obstetrics and gynaecology »Mala Bogorodica« – Sistina Medical, Skopje, R. Macedonia
Slobodan Lazarevski
; Special hospital for obstetrics and gynaecology »Mala Bogorodica« – Sistina Medical, Skopje, R. Macedonia
Mihailo Popović
; Special hospital for obstetrics and gynaecology »Mala Bogorodica« – Sistina Medical, Skopje, R. Macedonia
Snežana Adamoska
; Special hospital for obstetrics and gynaecology »Mala Bogorodica« – Sistina Medical, Skopje, R. Macedonia
Aneta Anevska
; Special hospital for obstetrics and gynaecology »Mala Bogorodica« – Sistina Medical, Skopje, R. Macedonia
Ana-Marija Stefanovska
; Special hospital for obstetrics and gynaecology »Mala Bogorodica« – Sistina Medical, Skopje, R. Macedonia
Abstract
The aim of this study is to determine the predictive capacity of BAFC measurements in the prediction of IVF outcome with regard to both ovarian response and pregnancy rates. Methods. Transvaginal ultrasound was performed on day 2–3 of the stimulation cycle, after ovarian down-regulation and before beginning treatment with gonadotropins. All ovarian follicles measuring 2 mm to 10 mm on both ovaries were counted by a single investigator. Patients were examined vaginally with an ATL transvaginal transducer (HDI 5000 diagnostic ultrasound system; Bothell, WA; USA). In total, 85 patients aged 24–42 years who underwent IVF/ICSI cycles were included in this prospective study. The patients were divided into two groups: group 1 patients who had basal antral follicle count 10 and group 2 patients who had basal antral follicles >10. Results. Basal antral follicle count correlated directly with number of follicles, number of mature oocytes, number of embryos and peak E2 levels. We failed to show any significant effect of basal antral follicle count on pregnancy rates. Furthemore, basal antral follicle count correlated inversely with ampoules of gonadotropin used, days of stimulation, patient age, and day 3 FSH levels. Nevertheless, transvaginal ultrasound ovarian measurements can predict poor response, thereby allowing physicians to inform patients that they are at an increased risk for poor stimulation and cycle cancellation. Physicians can then potentially optimize stimulation protocols. Conclusion. Based on the results of this study, we suggest using a higher starting dose of gonadotropin in women with an antral follicle count of 10 and a -lower starting dose of gonadotropin in women with an antral follicle count of >10.
Keywords
basal antral follicle count; ovarian response; pregnancy rates; ultrasound
Hrčak ID:
62082
URI
Publication date:
1.9.2008.
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