Original scientific paper

Histopathological alterations induced after oral sub-acute thiacloprid toxicity in Gallus domesticus

Saloni Goyal ; Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University Ludhiana, Punjab, India
Harpal S. Sandhu ; Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University Ludhiana, Punjab, India
Rajinder S. Brar ; Department of Veterinary Pathology, College of Veterinary Science, Guru Dev Veterinary and University Ludhiana, Punjab, India

Abstract

Repeated oral administration of 10 mg/kg/day thiacloprid, a neonicotinoid insecticide, for 28 consecutive days in Gallus domesticus, resulted in significant changes in the gross morphology of liver, lungs and intestine but no alterations in the kidneys, brain, heart and ovaries. Histopathologically significant alterations in the liver were observed, such as mild fatty changes, congestion and degeneration of hepatocytes. Alterations in the histoarchitecture of the kidneys included marked congestion, tubular cell degeneration and sloughing of epithelial cells. The cerebral hemisphere revealed changes comprising of mild neuronal degeneration with surrounding glial cells, satellitosis and vacuolation. Mild congestion and haemorrhage was observed in the lungs and myocardial tissues following oral administration of thiacloprid. No adverse effect on the ovarian histoarchitecture and thus the reproductive performance of Gallus domesticus was seen. The oral sub-acute toxicity study of thiacloprid revealed that this neonicotinoid insecticide is of moderate risk in Gallus domesticus

Keywords

Gallus domesticus; thiacloprid; neonicotinoid; histopathology

Hrčak ID:

62161

URI

https://hrcak.srce.hr/62161

Publication date:

26.10.2010.

Article data in other languages: croatian

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