Croatica Chemica Acta, Vol. 83 No. 4, 2010.
Original scientific paper
Electrochemical Behavior and Electrochemical Determination of Tiamulin Fumarate at an Ionic Liquid Modified Carbon Paste Electrode
Li-Hong Liu
; Key Lab of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, People's Republic of China; Department of Chemistry, Heihe College, Heihe 164300, People's Republic of China
Cheng-Qian Duan
; Key Lab of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, People's Republic of China
Zuo-Ning Gao
; Key Lab of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, People's Republic of China
Abstract
The electrochemical behavior of tiamulin fumarate (TF) at ionic liquid N-Butylpyridinium hexafluorophosphate
(BPPF6) modified carbon paste electrode (BPPF6/CPE) was investigated and further used
for tiamulin fumarate sample determination. BPPF6/CPE showed an enhanced electrochemical response
towards the electrochemical oxidation of TF. A well-defined and sensitive oxidation peak was observed at
BPPF6/CPE in 0.10 M phosphate buffer solution (PBS, pH = 6.80). The oxidation peak current of TF increased
significantly at BPPF6/CPE compared with that at carbon paste electrode and the BPPF6/CPE was
characterized by the electrochemical impedance spectroscopy (EIS). At the same time, the electrochemical
kinetics parameters of TF on the BPPF6/CPE were evaluated. Under the optimized conditions, the oxidation
peak currents were linearly dependent on the concentration of TF in the range of 0.3–9.0 μM and
9.0–0.3 mM, with a detection limit of 0.16 μM (S/N = 3). The proposed method has been successfully applied
in the electrochemical quantitative determination of TF content in commercial injection samples.
Keywords
Tiamulin fumarate; Ionic liquid modified carbon paste electrode; Electrochemistry; Electrochemical determination
Hrčak ID:
62645
URI
Publication date:
1.12.2010.
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