Original scientific paper
The Influence of the Different Morphological Changes on Gastric Mucosa on Somatostatin Cell Number in Antrum Mucosa and Serum Somatostatin
Silvio Mihaljević
Miroslava Katičić
Željko Krznarić
Branko Dmitrović
Ivan Karner
Mario Štefanić
Ljerka Pinotić
Marina Samardžija
Mirta Benšić
Abstract
The aim of our paper was to investigate the influence of the different morphological changes on gastric mucosa on
somatostatin D-cell number in antral mucosa and serum Somatostatin. We analyzed according to Sydney classification
to what extent the severity of gastritis affect the observed hormonal values. somatostatin D-cell number in antral mucosa
and serum Somatostatin values were compared between three grups of patients; mild, moderate and severe cronic gastritis.
The average number of somatostatin cell in biopsy sample of antrum mucosa was 30.41±35.38 (N=17) in the case of
middle form, 18.69±26.65 (N=56) in moderate and in severe case of chronic gastritis 5.23±5.93 (N=7) cells in mm² of
mucosa. The level of somatostatin in the serum of middle form gastritis were 26.43±28.76, moderate 19.95±35.93 and severe
17.88±17.66 pg/mL. In order to determine the number of somatostatin cells in antrum mucosa and serum somatostatin
with present morphological changes of mucosa, it might helpful to exclude the patients with non-ulcer dyspepsia,
but with the higher risk of premalignant and malignant changes.
Keywords
chronic gastritis; somatostatin D-cell; serum somatostatin
Hrčak ID:
64721
URI
Publication date:
7.3.2011.
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