Original scientific paper

Glycolipoprotein G-90 obtained from the earthworm Eisenia foetida exerts antibacterial activity.

Maja Popović ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Mira Grdiša ; Institut Ruđer Bošković, Zagreb, Croatia
Terezija Mihaela Hrženjak ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Croatia

Abstract

G-90 is a glycolipoprotein mixture obtained from the tissue homogenate of earthworm Eisenia foetida (Annelida, Lumbricidae) which exhibits pleiotropic biological functions. The antibacterial activity of G-90 was investigated in vitro and in vivo. Concentrations of 10 ng/mL and 10 μg/mL of G-90 exhibited an inhibitory effect on in vitro growth of non-pathogenic and facultative-pathogenic bacteria. The bacteriostatic effect of the G-90 was 21% stronger for facultative-pathogenic bacteria than that observed for non-pathogenic bacteria. The analysis of CFU/mL values following swabbing of surgical wounds in mice demonstrated that G-90 used in either 10 ng/mL or 10 μg/mL concentrations inhibited in vivo growth of the bacteria obtained from these wounds. The antibacterial activity of G-90, as well as the biological characteristics exhibited by the preparation, may be of interest for clinical investigations in veterinary and human medicine.

Keywords

earthworm; Eisenia foetida; G-90; antibacterial activity

Hrčak ID:

67397

URI

https://hrcak.srce.hr/67397

Publication date:

20.4.2005.

Article data in other languages: croatian

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