Original scientific paper
PLACENTAL GROWTH FACTOR IN MOTHER’S AND UMBILICAL CORD BLOOD IN PREGNANT WOMEN SUFFERING FROM TYPE-1 DIABETES MELLITUS
Jozo Blajić
; Department of Obstetrics and Gynecology, Clinical Medical Center Zagreb,School of Medicine University of Zagreb, Petrova 13, Zagreb, Croatia
Aleksandar Dijaković
; Department of Obstetrics and Gynecology, Clinical Medical Center Zagreb,School of Medicine University of Zagreb, Petrova 13, Zagreb, Croatia
Marina Ivanišević
orcid.org/0000-0001-6478-1174
; Department of Obstetrics and Gynecology, Clinical Medical Center Zagreb,School of Medicine University of Zagreb, Petrova 13, Zagreb, Croatia
Josip Juras
orcid.org/0000-0002-1801-5732
; Department of Obstetrics and Gynecology, Clinical Medical Center Zagreb,School of Medicine University of Zagreb, Petrova 13, Zagreb, Croatia
Josip Đelmiš
orcid.org/0000-0002-7332-5936
; Department of Obstetrics and Gynecology, Clinical Medical Center Zagreb,School of Medicine University of Zagreb, Petrova 13, Zagreb, Croatia
Tomislav Župić
; Department of Obstetrics and Gynecology, Clinical Medical Center Zagreb,School of Medicine University of Zagreb, Petrova 13, Zagreb, Croatia
Abstract
Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are key factors in physiological and pathological conditions of pregnancy. We investigated whether serum levels of PlGF in mother’s and umbilical blood are different between healthy pregnant women and pregnant women suffering from type-1 diabetes mellitus. We performed a prospective study of 44 pregnant women with type 1 diabetes who did not have diabetic complications and of 34 healthy pregnant women of the adequate age and parity and the normal pregnancy course. Venous blood samples were collected from 8th weeks of pregnancy during the whole pregnancy, in distance from 4 weeks. Results are expressed as means±standard deviations. Statistical analysis was performed using ANOVA, Student t-test, linear regression, and non-parametrical Mann-Whitney U test. PlGF level in diabetic and healthy pregnant women from the 8th till the 15th week of pregnancy is comparatively low (23.16±4.94 pg/mL : 21.68 ±4.91 pg/mL), and after the 15th week of pregnancy it increases fast till the 31st week of pregnancy when the value is the highest (440.77±173.03 pg/ml : 390.41±138.07 pg/mL). After the 31st week of pregnancy there is a decrease of PlGF levels. Comparing PlGF values between the research groups in defined weeks of pregnancy no statistically significant difference was found. PlGF values in serum of healthy and diabetic pregnant women do not differ in same weeks of pregnancy. PlGF values in mother’s and fetal serum immediately after the birth are a bit lower (but not statistically significant) in diabetic pregnant women in relation to a control group. A statistically significant correlation coefficient was found between PlGF level and a newborns weight and between PlGF and placenta weight. A statistically significant correlation coefficient was found between PlGF level of mother’s blood and umbilical vein.
Keywords
Placental growth factor; diabetic pregnancy
Hrčak ID:
68365
URI
Publication date:
1.3.2010.
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