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Original scientific paper

Hypolipemic effect of Kuub (Gundelia tourefotti A.) oil and clofibrate on lipid profile of atherosclerotic rats.

Khalid Hammadi Sharaf ; Department of Physiology, College of Veterinary Medicine, University of Mosul, Mosul IRAQ
Jian Salam Ali ; Department of Physiology, College of Veterinary Medicine, University of Mosul, Mosul IRAQ

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page 359-369

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Two major groups of albino adult male rats were used as a biological model for this study. The first group contained five healthy rats (healthy control group), and the second group twenty-five atherosclerotic rats induced by hydrogen peroxide and cholesterol, which were divided equally into five subgroups. The first subgroup was orally treated with sunflower oil (atherosclerotic rats control group). The second subgroup was treated with 300 mg clofibrate drug/kg rat body mass (hypolipidemic reference group). The third, forth and fifth subgroups were orally treated with 60, 90 and 120 mg Kuub (Kanger) oil/kg body mass, respectively. Blood samples were collected from retro-ocular eye vein using a heparinized pack cell volume (PCV) tube. In plasma, total lipid (TL), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and liver total cholesterol (TC) were determined. Nutritional status of the rats was also estimated. Results showed that the Kuub oil caused an improvement in the nutritional status of the rats, with hypolipidemic effect in plasma TL, TC, very low density lipoprotein-cholesterol and low density lipoprotein-cholesterol (VLDL-C + LDL-C), and decreased atherogenic indices. On the other hand, there was an increase in plasma HDL-C value and a decrease in liver TC level of atherosclerotic rats. Oil extract of Kuub seeds with a concentration of 90 mg/kg body mass is considered to give high efficacy concentration than the other tested ones. However, its hypolipidemic effect is lower than the clofibrate.


rat, atherosclerosis, hypolipidemia, lipid profile, cholesterol, clofibrate, hydrogen peroxide, Kuub

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