Review article

Anaestethic technique and cytokine response

KATARINA ŠAKIĆ orcid.org/0000-0001-5413-6382 ; Department of Anaesthesiology, Reanimatology and Intensive Medicine, University Hospital Sv Duh, Zagreb, Croatia
MARIJANA ŽURA ; University Hospital Center, Zagreb, Croatia
LIVIJA ŠAKIĆ ; 4Policlinic for maxillofacial, general and plastic surgery Bagatin, Zagreb, Croatia
BRANKO MALENICA ; Department of Immunology, University Hospital Center-Zagreb, Croatia
DINKO BAGATIN ; Policlinic for maxillofacial, general and plastic surgery Bagatin, Zagreb, Croatia
DEANA ŠTURM ; Clinic Hospital Centre »Sister of Mercy«, Zagreb, Croatia

Abstract

Surgery elicits broad alterations in haemodynamic, endocrine-metabolic and immune responses. The inflammatory response is essential for structural and functional repair of injured tissue, as complement, granulocytes, macrophages and many other mediators are required for appropriate wound healing. Injury, surgical or traumatical is connected with the acute disorder of immunological system which is manifesting as increased inclination to infections. The inflammatory response is an important determinant of outcome after major surgery. Perioperative excessive stimulation of the inflammatory and haemostatic systems plays a role in the development of postoperative ileus, ischaemia-reperfusion syndromes (e.g. myocardial infarction), hypercoagulation syndromes (e.g. deep venous thrombosis) and pain; together, these represent a significant fraction of major postoperative disorders. Regional anaestehsia administered local anaesthetics prevent or
modulate many of these processes.

In the center of interests there are the serum-levels of Th1 i Th2 cytokines before and after regional and general anaesthesia and in such a way would like to confirm through the immunological status that the spinal anaesthesia is significantly more favourable for the patient.

Keywords

Hrčak ID:

68918

URI

https://hrcak.srce.hr/68918

Publication date:

1.6.2011.

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