Original scientific paper
Salivary Analytes in Patients with Oral Squamous Cell Carcinoma
Petra Nola Fuchs
Dunja Rogić
Danica Vidović-Juras
Mato Sušić
Aleksandar Milenović
Vlaho Brailo
Vanja Vučićević Boras
Abstract
Literature data indicates that measurement of certain salivary constituents might serve as a useful diagnostic/prognostic
tool in the patients with oral squamous cell carcinoma (OSCC). In 24 patients with OSCC (60±2.5yrs) and in 24
controls (24±3.7yrs) we have determined levels of salivary magnesium, calcium, copper, chloride, phosphate, potassium,
sodium, total proteins and amylase. Sodium, potasium and chloride were determined by indirect potentiometry whereas
copper, magnesium and phosphate were determined by atomic absorption spectrophotometry. Total proteins were determined
by pyrogalol colorimetric method. Amylase levels were determined by continued colorimetric method. Statistical
analysis was performed by use of c2 test and Spearman´s correlation test. The results of this study indicate that the concentrations
of sodium and chloride were significantly elevated in patients with OSCC when compared to the controls.
However, level of total protein was significantly decreased when compared to the healthy controls. Furthermore, there
was a negative correlation between alcohol consumption and total protein concentration in patients with oral carcinoma.
We might conclude that in patients with OSCC increased salivary sodium and chloride might reflect their overall dehydration
status due to alcohol consumption rather than consequence of OSCC iteself.
Keywords
oral squamous cell carcinoma; saliva
Hrčak ID:
68945
URI
Publication date:
24.6.2011.
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