Short communication, Note

https://doi.org/10.2478/v10007-011-0031-5

Assay of lercanidipine hydrochloride in dosage forms using nucleophilic substitution reaction

THUTTAGUNTA MANIKYA SASTRY ; Department of Chemistry, G V P College of Engineering, Visakhapatnam–530047, India
KARIPEDDI RAMAKRISHNA ; Department of Chemistry, Institute of Science, GITAM University, Visakhapatnam-530045, India

Abstract

A simple and sensitive spectrophotometric method has been developed for the assay of lercanidipine hydrochloride (LER) in bulk and in formulations. The method is based on the formation of coloured species between the drug and 1,2-naphthaquinone-4-sulphonic acid sodium salt (NQS) by means of nucleophilic substitution reaction. The absorbance was measured at max = 460. The method was analyzed statistically. The system obeyed the Beer’s law in the range 20100 g mL1. Molar absorptivity value was found to be 4.79 × 103 L mol1 cm1. Limits of detection and quantification were found to be as low as 0.04 and 0.13 g mL1. Precision (RSD, 0.4 %) and accuracy (recovery 99.2 ± 0.6 to 101.1 ± 0.8 %) of the developed method were evaluated.

Keywords

spectrophotometry; lercanidipine hydrochloride; 1,2-naphthaquinone-4-sulphonic acid sodium salt (NQS)

Hrčak ID:

71377

URI

https://hrcak.srce.hr/71377

Publication date:

31.12.2011.

Article data in other languages: croatian

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