Acta Pharmaceutica, Vol. 61 No. 4, 2011.
Short communication, Note
https://doi.org/10.2478/v10007-011-0036-0
Liquid antisolvent precipitation process for solubility modulation of bicalutamide
TARIQUE ALI MEER
; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, India
KIRAN P. SAWANT
; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, India
PURNIMA D. AMIN
; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, India
Abstract
Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E5 and Poloxamer 407 were shortlisted as a hydrophilic polymer and surfactant, respectively, for the process. Process optimization was done with respect to the hydrophilic polymer, surfactant and drug loading concentration. The resultant microcrystals were characterized with various instrumental techniques for material characterization such as IR, DSC, SEM, XRD, particle size, specific surface area and dissolution kinetics.
Keywords
bicalutamide; solubility enhancement; dissolution rate; liquid antisolvent precipitation
Hrčak ID:
71382
URI
Publication date:
31.12.2011.
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