Original scientific paper
https://doi.org/10.2478/10004-1254-62-2011-2122
Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro
Ksenija Durgo
; Faculty of Food Technology and Biotechnology, Zagreb, Croatia
Ivana Halec
; Faculty of Food Technology and Biotechnology, Zagreb, Croatia
Ivana Šola
; Faculty of Natural Sciences, Zagreb, Croatia
Jasna Franekić
; Faculty of Food Technology and Biotechnology, Zagreb, Croatia
Abstract
Quercetin is the main fl avonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases. Due to its specifi c planar chemical structure, quercetin readily forms chelates with metalions. Complexes of bioactive compounds and metal ions such as lanthanum often show strong
cytotoxic and antitumour properties. The aim of this study was to compare the genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells with compare it to the effects of free ligands, quercetin, and lanthanum alone. The quercetin/lanthanum complex showed considerable cytotoxicity in the concentration range of (100 to 1000) mmol mL-1 and exposure time of three hours. The complex also induced a dose-dependent pro-oxidative effects and the formation of single-strand and double-strand DNA breaks. Although we obtained promising results on the cell level, future experiments should answer whether the quercetin/lanthanum complex is cancer-specific and stable enough in
physiological conditions to make a potential new antitumour drug.
Keywords
chelates; DNA damage; flavonoid/metal complexes, oxidative damag
Hrčak ID:
71765
URI
Publication date:
23.9.2011.
Visits: 2.505 *