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Croatica Chemica Acta, Vol. 84 No. 2, 2011.

Review article

https://doi.org/10.5562/cca1817

Neurochemical and Behavioural Changes in Rat Models of Depression

Ivan Skelin ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada
Tomislav Kovačević ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia
Mirko Diksic orcid id orcid.org/0000-0001-8070-6051 ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

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Abstract

Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence.
The study of human depression is hindered by the relatively significant heterogeneity of this disorder.
As a result of these heterogeneities, studies using a sound and representative animal model of depression
are extremely valuable and, in general, provide important information regarding the neurochemical/
biological changes occurring during depression and the subsequent treatment of its symptoms. In this
review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and
Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics
of a good animal model; face, predictive and constructive validities. We also emphasize the
brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi:
10.5562/cca1817)

Keywords

depression; olfactory bulbectomized rat model of depression; Flinders sensitive line rat; Flinders Resistant line rat; animal model of depression

Hrčak ID:

71992

URI

https://hrcak.srce.hr/71992

Publication date:

3.10.2011.

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