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Collegium antropologicum, Vol. 35 - supplement 2 No. 2, 2011.

Original scientific paper

Anti – VEGF in Treatment of Diabetic Macular Edema

Ivan Boras
Ratimir Lazić
Nikica Gabrić
Marko Lukić
Iva Dekaris

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Abstract

Diabetic macular edema is the leading cause of moderate visual deterioration in patients with diabetic retinopathy.
Ranibizumab) blocks vascular endothelial growth factor (VEGF) induced hyperpermeability of blood vessels. In this prospective
case series we investigated the efficacy and safety of anti-VEGF treatment in reduction of central retinal thickness
(CRT) and improvement in visual acuity (VA) in patients with diabetic macular edema (DME). 9 patients were followed
up for 6 months and treated monthly with intravitreal ranibizumab. VA and CRT were measured at each visit.
Treatment was discontinued as the peak improvement of either parameter was reached and reinstituted in case of deterioration/
recurrence of edema. Study endpoints included: VA using ETDRS chart, CRT and number of injections at 6
months. Mean VA from all 9 patients increased by 0.3 lines of logMAR (p<0.05 compared to baseline), and CRT decreased
from 515 ± 123 mm to 310 ± 110 mm. The improvement of VA after ranibizumab injection was in correlation with
a decrease in CRT. Mean of 4 injections were needed to control the disease during the follow-up period. Ranibizumab
treatment was effective in VA and reducing CRT. Several injections were needed to control the disease. Regular OCT examinations
and retreatment are advised in order to maintain initially reached VA.
Abbreviations: DME – diabetic macular edema, VEGF – vascular endothelial growth factor, CRT – central retinal
thickness, VA – visual acuity, ETDRS – early treatment diabetic retinopathy study, OCT – optical coherence tomography,
SOCT – spectral domain optical coherence tomography, IDDM – insulin dependent diabetes mellitus, NIDDM – non-insulin
dependent diabetes mellitus.

Keywords

diabetic retinopathy; diabetic macular edema; anti-vascular endothelial growth factor therapy; ranibizumab

Hrčak ID:

72217

URI

https://hrcak.srce.hr/72217

Publication date:

25.9.2011.

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