Original scientific paper

Cefotaxime pharmacokinetics in buffalo calves following multiple dosing.

Suresh Kumar Sharma ; Department of Pharmacology and Toxicology, College of Veterinary Science Punjab, Agricultural University, Ludhiana, India
Anil Kumar Srivastava ; Department of Pharmacology and Toxicology, College of Veterinary Science Punjab, Agricultural University, Ludhiana, India

Abstract

The pharmacokinetic pattern of cefotaxime following its repeated dosing was studied in buffalo calves. Cefotaxime was given at a dose rate of 13 mg/kg, first by intravenous route (i.v.) followed by intramuscular (i.m.) administration, 8 hourly for 5 days. Plasma levels of cefotaxime equivalent at different pre-determined time intervals were estimated. At 1 min, after first i.v. injection, plasma level was 71.7 ± 6.01 μg.ml-1, which gradually declined and drug was detected up to 8 h (0.09 ± 0.05 μg.ml-1). Plasma concentration of cefotaxime equivalent at 15, 20, 30 and 480 min following all repetitions was almost the same. After final intramuscular injection, peak plasma concentration (11.0 ± 0.24 μg.ml-1) was detected at 20 min, which declined to 0.08 ± 0.04 μg.ml-1 at 8 h. On comparing the data on plasma levels of repeated intramuscular injections with first intravenous injection, it was revealed that repeated intramuscular injections of cefotaxime have no prolonged therapeutic effect and lack any cumulative effect. Perusal of kinetic determinants of cefotaxime following first i.v. injection and last i.m. injection revealed no significant difference in relation to β, t1/2β, AUC, Vd(area) and ClB. Such lack of variation indicated that repeated administration of cefotaxime did not alter its disposition kinetics.

Keywords

buffalo calves; cefotaxime; multiple dosing; pharmacokinetics

Hrčak ID:

74404

URI

https://hrcak.srce.hr/74404

Publication date:

20.8.2003.

Article data in other languages: croatian

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