Short communication, Note

THE EFFECT OF OLANZAPINE AND SERTRALINE ON PERSONALITY DISORDER IN PATIENTS WITH METHADONE MAINTENANCE THERAPY

Mojhgan Jariani ; Lorestan University of Medical Sciences, Tehran, Iran
Mandana Saaki ; School of Nursing and Midwifery, Lorestan University of Medical, Tehran, Iran
Hedayat Nazari ; Lorestan University of Medical Sciences, Tehran, Iran
Mehdi Birjandi ; School of Public Health, Lorestan University of Medical Sciences, Tehran, Iran

Abstract

Background: Various drugs have been suggested for treatment of Borderline Personality Disorder (BPD)-a disabling disease
affecting two percent of the general population. If a drug could alleviate a wide range of symptoms, it would be more suitable. In
these disorders drug addiction is very common. This fact makes the symptoms complicated and the treatment more difficult.
Subjects and methods: This study is designed to evaluate the effect of Olanzapine and Sertraline in patients suffering from
personality disorders who are on methadone maintenance therapy. This study is a clinical trial. 120 males and females were chosen
for methadone maintenance therapy through interview by a psychiatrist based on DSM-IV-TR diagnostic criteria for BPD.
Afterwards they were randomly divided into two groups. These groups separately received Olanzapine (5-10 mg daily) and
Sertraline (50-100 mg daily) therapy. The SCL-90 questionnaire was filled by all participants before treatment and at the 4th, 8th and
12th weeks of treatment.
Results: According to this clinical trial, Olanzapine and Sertraline are effective in ameliorating symptoms of depression, anxiety
and aggression, reducing sensitivity in interpersonal relationships and alleviating obsessive symptoms, pessimistic behaviors and
somatization disorders in patients with personality disorders on methadone maintenance therapy.
Conclusion: As result of this study it appears that Olanzapine and Sertraline are definitely effective in alleviating symptoms of
patients with personality disorder, prescribing theses drugs are recommended for these patients.

Keywords

borderline personality disorder; methadone maintenance therapy; Olanzapine; Sertraline

Hrčak ID:

76377

URI

https://hrcak.srce.hr/76377

Publication date:

8.12.2010.

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