Original scientific paper
https://doi.org/10.2478/10004-1254-63-2012-2190
Effects of Myosmine on Antioxidative Defence in Rat Liver
Rumyana Simeonova
; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology,Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Vessela Vitcheva
; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology,Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Galina Gorneva
; Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Mitka Mitcheva
; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology,Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Abstract
Myosmine [3-(1-pyrrolin-2-yl) pyridine] is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we investigated the effects of myosmine on enzymatic and nonenzymatic antioxidative defence in rat liver. Wistar rats received a single i.p. injection of 19 mg kg-1 of myosmine and an oral dose of 190 mg kg-1 by gavage. Nicotine was used as a positive control. Through either route of administration, myosmine altered the hepatic function by decreasing the levels of reduced glutathione, superoxide dismutase, and glutathione peroxidase activities on one hand and by increasing malondialdehyde, catalase, and glutathione reductase activity on the other. Compared to control, both routes caused significant lipid peroxidation in the liver and altered hepatic enzymatic and non-enzymatic antioxidative defences. The pro-oxidant effects of myosmine were comparable with those of nicotine.
Keywords
lipid peroxidation; oxidative stress; rodents; tobacco alkaloid
Hrčak ID:
78631
URI
Publication date:
21.3.2012.
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