Original scientific paper
Quantitative Analysis of Troponin I Serum Values in Patients with Acute Cholecystitis
Žarko Babić
Zoran Bogdanović
Zdravko Dorosulić
Merita Basha
Željko Krznarić
Ivo Sjekavica
Milan Kujundžić
Mario Tadić
Marko Banić
Vjekoslav Jagić
Marinko Marušić
Abstract
The diagnosis and staging of acute cholecystitis, upon a lot of diagnostic methods and some scoring systems, is still a great clinical problem. The aim of the study was to investigate if serum Troponin I is elevated in patients with acute cholecystitis. Following informed consent, 65 patients with clinical and laboratory signs of acute cholecystitis were enrolled. All patients had measured serum Troponin I level and an abdominal ultrasound was done before definitive treatment was performed. Increased serum Troponin I level was found in most patients with severe form of acute cholecystitis (p<0.00001). It reached sensitivity of 94.5% and specificity of 57.1% of this test. In multiple regression analysis Troponin I significantly correlated (p<0.05) with the serum aspartate aminotransferase (r=0.27), gamma- -glutamyl transferase (r=0.25) and gallbladder wall (>6 mm) thickness (r=0.58). Our study confirms that in most patients with severe and acute cholecystitis, serum Troponin I is increased. Troponin I level is in a lower range than it would be in patients with cardiac muscle damage or necrosis. Measuring serum Troponin I is a fast, reliable and widely performed test that could, with other routinely measured parameters, help in early diagnosis of the severe form of acute cholecystitis.
Keywords
acute cholecystitis; Troponin Ic; staging
Hrčak ID:
78804
URI
Publication date:
28.3.2012.
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