Original scientific paper

https://doi.org/10.2478/v10007-012-0014-1

The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

SORACHAI KHAMSAN ; Faculty of Pharmacy, Department of Pharmaceutical Science, Chiang Mai University, Chiang Mai, 50200 Thailand
SAISUNEE LIAWRUANGRATH ; Faculty of Science, Department of Chemistry and Center for Innovation in Chemistry, Chiang Mai University, Chiang Mai, 50200 Thailand
APHIWAT TEERAWUTKULRAG ; Faculty of Science, Department of Chemistry and Center for Innovation in Chemistry, Chiang Mai University, Chiang Mai, 50200 Thailand
STEPHEN G. PYNE ; School of Chemistry, University of Wollongong, Wollongong, NSW, 2522 Australia
MARY J. GARSON ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072 Australia
BOONSOM LIAWRUANGRATH ; Faculty of Pharmacy, Department of Pharmaceutical Science, Chiang Mai University, Chiang Mai, 50200 Thailand

Abstract

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids ()-liquiritigenin (1), ()-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 µg mL1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).

Keywords

Jacaranda obtusifolia (Bignoniaceae); flavonoids; anticancer activity

Hrčak ID:

78865

URI

https://hrcak.srce.hr/78865

Publication date:

30.6.2012.

Article data in other languages: croatian

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