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Croatian Medical Journal, Vol. 53 No. 2, 2012.

Original scientific paper

Breast and gynecological cancers in Croatia, 1988-2008

Iva Kelava ; Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
Karlo Tomičić ; Department of Gynecology and Obstetrics, University Hospital Center Zagreb, Zagreb, Croatia
Marina Kokić ; Health Centre Zagreb (East), Zagreb, Croatia
Ante Ćorušić ; Department of Gynecology and Obstetrics, University Hospital Center Zagreb, Zagreb, Croatia
Pavao Planinić ; Department of Gynecology and Obstetrics, University Hospital Center Zagreb, Zagreb, Croatia
Iva Kirac ; Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
Jure Murgić ; Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
Tomislav Kuliš ; Department of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Ariana Znaor ; Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia

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Abstract

Aim To analyze and interpret incidence and mortality
trends of breast and ovarian cancers and incidence trends
of cervical and endometrial cancers in Croatia for the period
1988-2008.
Methods Incidence data were obtained from the Croatian
National Cancer Registry. Themortality data were obtained
from the World Health Organization (WHO) mortality database.
Trends of incidence and mortality were analysed by
joinpoint regression analysis.
Results Joinpoint analysis showed an increase in the incidence
of breast cancer with estimated annual percent of
change (EAPC) of 2.6% (95% confidence interval [CI], 1.9 to
3.4). The mortality rate was stable, with the EAPC of 0.3%.
Endometrial cancer showed an increasing incidence trend,
with EAPC of 0.8% (95% CI, 0.2 to 1.4), while cervical cancer
showed a decreasing incidence trend, with EAPC of -1.0
(95% CI, -1.6 to -0.4). Ovarian cancer incidence showed
three trends, but the average annual percent change
(AAPC) for the overall period was not significant, with a stable
trend of 0.1%. Ovarian cancer mortality was increasing
since 1992, with EAPC of 1.2% (95% CI, 0.4 to 1.9), while the
trend for overall period was stable with AAPC 0.1%.
Conclusion Incidence trends of breast, endometrial, and
ovarian cancers in Croatia 1988-2008 are similar to the
trends observed in most of the European countries, while
the modest decline in cervical cancer incidence and lack
of decline in breast cancer mortality suggest suboptimal
cancer prevention and control.

Keywords

Hrčak ID:

82899

URI

https://hrcak.srce.hr/82899

Publication date:

15.4.2012.

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