Original scientific paper
Lamellar body count as a diagnostic test in predicting neonatal respiratory distress syndrome
Tea Štimac
; Department of Gynecology and Obstetrics, Perinatology Unit, University Hospital Rijeka, Rijeka, Croatia
Oleg Petrović
; Department of Gynecology and Obstetrics, Perinatology Unit, University Hospital Rijeka, Rijeka, Croatia
Robert Krajina
; Department of Gynecology and Obstetrics, Perinatology Unit, University Hospital Rijeka, Rijeka, Croatia
Mirko Prodan
; Department of Gynecology and Obstetrics, Perinatology Unit, University Hospital Rijeka, Rijeka, Croatia
Lidija Bilić-Zulle
; Clinical Department of Laboratory Diagnosis, University Hospital Center Rijeka and Department of Medical Informatics, Rijeka University School of Medicine, Rijeka, Croatia
Abstract
Aim To determine the lamellar body count (LBC) cutoff
value for fetal lung maturity and to evaluate the clinical
usefulness of LBC in predicting the severity of neonatal respiratory
distress syndrome (RDS).
Methods A prospective study was conducted from 2002
until 2010. LBC was estimated in uncentrifugated amniotic
fluid samples using Cell-Dyn 1800 analyzer. Amniotic fluid
samples were obtained by amniocentesis or by puncturing
embryonic membranes during cesarean section. The
presence of mild, moderate, and severe RDS was assessed
by neonatologist.
Results A total of 313 patients with singleton pregnancies
(24-41 weeks) were included in the study and 294 met
the inclusion criteria. RDS was diagnosed in 28 neonates –
mild in 8, moderate in 10, and severe in 10. In premature
neonates (<37 gestational weeks), significant differences
in LBC were only found between the subgroup without
RDS and the group with moderate and the group with severe
RDS (P < 0.001). In all neonates, significant differences
were found between neonates without RDS and neonates
with RDS. Using LBC cutoff value of ≥20,000/μL, sensitivity,
specificity, and positive and negative predictive values
of LBC in determining mature fetal lungs were 96%, 88%,
45.6%, and 99.5%, respectively.
Conclusion This study suggests that LBC cutoff value of
≥20,000/μL can predict pulmonary maturity and reduce
the risk of neonatal respiratory distress syndrome.
Keywords
Hrčak ID:
84158
URI
Publication date:
15.6.2012.
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