Original scientific paper

https://doi.org/10.5562/cca1779

Clinical Relevance of CD-68 Positive Cells in Normal Buccal Mucosa in Patients with Inflammatory Bowel Disease

Brankica Mijandrušić Sinčić ; Department of Gastroenterology, University Hospital Centre Rijeka, Rijeka, Croatia
Maja Ilić Tomaš ; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Margita Belušić Gobić ; Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia
Mirna Juretić ; Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia
Dražen Kovač ; Department of Pathology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Andrica Lekić ; Department of Physics, Medical Faculty, University of Rijeka, Rijeka, Croatia
Ester Pernjak Pugel ; Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia
Robert Cerović ; Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia
Davor Štimac ; Department of Gastroenterology, University Hospital Centre Rijeka, Rijeka, Croatia

Abstract

The aim of this study was to investigate the presence of microaggregates of macrophages (CD-
68 positive cells) in macroscopically normal buccal mucosa in patients with inflammatory bowel disease
(IBD). Fifty two patients with clinically and pathohistologically diagnosed IBD, thirty patients with
Crohn’s disease (CD), twenty two patients with ulcerative colitis (UC), and twenty five controls, matched
for sex and age, were involved. The occurrence of CD-68 positive cells microaggregates was more frequent
in CD patients comparing with UC patients (P = 0.0093), and the controls (P = 0.0001) respectively.
There was no statistically significant difference in occurrence of CD-68 positive microaggregates in
patients with positive microbiological findings (P = 0.8258). The results suggest that microaggregates of
macrophages are more frequently present in apparently normal buccal mucosa in patients with CD than in
patients with UC independently of microbiological findings. Therefore, it could be a potential marker for
differentiating patients with Crohn’s disease from UC patients, when standard tools failed. (doi:
10.5562/cca1779)

Keywords

CD-68 microaggregates; buccal mucosa; CD; UC; predictive factors

Hrčak ID:

84529

URI

https://hrcak.srce.hr/84529

Publication date:

11.5.2012.

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