Original scientific paper

https://doi.org/10.5562/cca1863

Is Dipeptidyl Peptidase IV (DPP IV) Associated with Inflammation Present in Human Spondyloarthritides and Rheumatoid Arthritis?

Dijana Detel ; Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Tatjana Kehler ; Department of Rheumatology, Thalassotherapy Hospital Opatija, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Sunčica Buljević ; Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Irena Pavačić ; School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Lara Batičić Pučar ; Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Neven Varljen ; Department of Physical Medicine and Rehabilitation, Thalassotherapy Hospital Opatija, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Jadranka Varljen ; Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia

Abstract

Dipeptidyl peptidase IV (DPP IV) is a serine peptidase which has been suggested to play a role
in the pathogenesis of rheumatoid arthritis, but its mediator actions have not been well investigated in patients
with spondyloarthritides. The purpose of this study was to investigate clinical relevance of changes
in serum DPP IV activity and concentration in these diseases. Serum DPP IV activity was significantly
decreased in patients with spondyloarthritides and rheumatoid arthritis compared to the control group,
while DPP IV concentration was increased. Among spondyloarthritides patients, DPP IV concentration
was decreased in patients with reactive arthritis. No difference was observed in DPP IV activity or concentration
between spondyloarthritides and rheumatoid arthritis, as well as between patients with clinically active
disease and those in remission. Our results suggest that DPP IV could not be used as a specific serum marker,
but could be potentially used as a non-specific inflammatory marker. (doi: 10.5562/cca1863)

Keywords

dipeptidyl peptidase IV; spondyloarthritides; rheumatoid arthritis

Hrčak ID:

84545

URI

https://hrcak.srce.hr/84545

Publication date:

11.5.2012.

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