Skip to the main content

Croatian Medical Journal, Vol. 53 No. 4, 2012.

Original scientific paper

Body composition and serum levels of adiponectin, vascular endothelial growth factor, and interleukin-6 in patients with rheumatoid arthritis

Sergey P. Oranskiy ; Kuban State Medical University, Krasnodar, Russian Federation
Ludmila N. Yeliseyeva ; Kuban State Medical University, Krasnodar, Russian Federation
Anna V. Tsanaeva ; Kuban State Medical University, Krasnodar, Russian Federation
Nadezhda V. Zaytseva ; Kuban State Medical University, Krasnodar, Russian Federation

Full text: english pdf 238 Kb

page 350-356

downloads: 637

cite

Abstract

Aim To investigate differences in body composition and
body mass index (BMI) in patients with rheumatoid arthritis
(RA) and their correlations with serum production of
adiponectin, interleukin-6 (IL-6), and vascular endothelial
growth factor (VEGF).
Methods The study included 83 patients (age 53 ± 5 years)
with RA treated with methotrexate. We determined their
BMI, fat mass, and fat-free mass using bioimpedance analysis,
and serum concentrations of adiponectin, VEGF, and
IL-6 using immunoassay analysis.
Results Normal BMI was found in 39 (47%), overweight and
obesity in 26 (31%), and underweight in 18 (22%) patients.
Concentration of adiponectin was lower in overweight/
obese patients than in patients with normal BMI (2.1 [0.8-
3.9] μg/mL vs 8.9 (7.2-11.3) μg/mL). In underweight patients,
it was moderately increased (12.7 [9.3-14.8] μg/mL)
and the correlation between the concentrations of adiponectin
and IL-6 was positive (r = 0.4; P = 0.01). Concentrations
of VEGF and IL-6 were increased in all groups with
RA. The overweight/obese group showed a negative correlation
between the concentrations of adiponectin and
VEGF (r = - 0.34; P = 0.04), a positive correlation between
VEGF concentration and fat mass (r = 0.39; P = 0.02), and a
negative correlation between adiponectin concentration
and fat mass (r = - 0.23; P = 0.02).
Conclusion Inflammatory and angiogenesis activation
was found in RA patients with all types of body composition,
but only in those with obesity and overweight there
was a direct antagonism between adiponectin and VEGF.
Further research is needed to identify possible regimens of
metabolic correction in different variations of body composition.

Keywords

Hrčak ID:

86019

URI

https://hrcak.srce.hr/86019

Publication date:

15.8.2012.

Visits: 1.289 *