Original scientific paper
https://doi.org/10.2478/10004-1254-63-2012-2179
Combined Effects of Cadmium and Decabrominated Diphenyl Ether on Thyroid Hormones in Rats
Marijana Ćurčić
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Saša Janković
; Institute of Meat Hygiene and Technology, Belgrade, Serbia
Vesna Jaćević
; Poison Control Center, Military Medical Academy, Belgrade, Serbia
Sanja Stanković
; Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Slavica Vučinić
; Poison Control Center, Military Medical Academy, Belgrade, Serbia
Ksenija Durgo
; Department for Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Zorica Bulat
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Biljana Antonijević
; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Abstract
The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg-1, 7.5 mg kg-1, or 15 mg kg-1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg-1, 2000 mg kg-1, or 4000 mg kg-1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
Keywords
BDE209; Cd; thyroid-stimulating hormone; thyroxin; triiodothyronin
Hrčak ID:
86882
URI
Publication date:
25.9.2012.
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