Original scientific paper

Simulation Models for Stem Cells Differentiation

M. Pisu ; Center for Advanced Studies, Research and Development in Sardinia (CRS4)
A. Concas ; Center for Advanced Studies, Research and Development in Sardinia (CRS4)
G. Cao ; University of Cagliari and Center for Advanced Studies, Research and Development in Sardinia (CRS4)

Abstract

A novel mathematical model to simulate stem cells differentiation into specialized cells of connective or non-connective tissues is discussed. The model is based upon material balances for extra cellular matrix compounds, growth factors and nutrients coupled
with a mass-structured population balance describing cell growth, proliferation and differentiation. The model is written in a general form and it may be used to simulate a generic cell differentiation pathway occurring in vivo or during in vitro cultivation when
specific growth factors are used. Several example are discussed where literature experimental data are successfully compared with model results, thus demonstrating the validity of the proposed model as well as its predictive capability.

Keywords

Stem cells differentiation; modeling; population; balance

Hrčak ID:

94208

URI

https://hrcak.srce.hr/94208

Publication date:

19.12.2012.

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