Skip to the main content

Croatian Medical Journal, Vol. 53 No. 6, 2012.

Original scientific paper

Electrophysiological predictors of propafenone efficacy in prevention of atrioventricular nodal re-entrant and atrioventricular re-entrant tachycardia

Hrvoje Pintarić ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivan Zeljković ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zdravko Babić ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mislav Vrsalović ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Nikola Pavlović ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Hrvojka Bošnjak ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Dubravko Petrač ; Department of Internal Medicine,Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Full text: english pdf 252 Kb

page 605-611

downloads: 495

cite

Abstract

Aim To assess the efficacy of propafenone in prevention of
atrioventricular nodal reentrant tachycardia (AVNRT) and
orthodromic atrioventricular tachycardia (AVRT) based on
the clinical results of arrhythmia recurrence and find the
electrophysiological predictor of propafenone effectiveness.
Methods This retrospective study included 44 participants
in a 12-month period, who were divided in two groups:
group A – in which propafenone caused complete ventriculo-
atrial block and group B – in which propafenone did
not cause complete ventriculo-atrial block.
Results Group A had significantly lower incidence of
tachycardia than group B (95% vs 70.8%, P = 0.038), and
complete ventriculo-atrial block predicted the efficacy of
propafenone oral therapy in the prevention of tachycardia
(sensitivity 87.5%, specificity 52.8%, positive predictive
value 95%, negative predictive value 29.2%). Patients with
AVNRT in group B who did not experience the recurrences
of tachycardia had significantly shorter echo zone before
intravenous administration of propafenone than the patients
who experienced episodes of sustained tachycardia
(median 40 ms [range 15-60 ms] vs 79 ms [range 50-180
ms], P = 0.008).
Conclusion In patients with non-inducible tachycardia,
complete ventriculo-atrial block can be used as an electrophysiological
predictor of the efficacy of propafenone oral
therapy in the prevention of tachycardia. In patients with
non-inducible AVNRT, but without complete ventriculoatrial
block, propafenone was more effective in patients
with shorter echo zone of tachycardia

Keywords

Hrčak ID:

95887

URI

https://hrcak.srce.hr/95887

Publication date:

15.12.2012.

Visits: 1.299 *