Short communication, Note

Neuroendocrine Tumors of Larynx – Two Case Reports and Literature Review

Tomislav Carić ; University of Zagreb, Dubrava University Hospital, Department of ENT, Head and Neck Surgery, Zagreb, Croatia
Mario Bilić ; University of Zagreb, Zagreb University Hospital Center, Department of ENT, Head and Neck Surgery, Zagreb, Croatia
Lana Kovač Bilić ; University of Zagreb, Zagreb University Hospital Center, Department of ENT, Head and Neck Surgery, Zagreb, Croatia
Drago Prgomet ; University of Zagreb, Zagreb University Hospital Center, Department of ENT, Head and Neck Surgery, Zagreb, Croatia
Jelena Kovačić ; University of Zagreb, Dubrava University Hospital, Department of ENT, Head and Neck Surgery, Zagreb, Croatia
Iva Topić Grahovac ; University of Zagreb, Zagreb University Hospital Center, Department of ENT, Head and Neck Surgery, Zagreb, Croatia
Zdenka Hutinec ; University of Zagreb, Zagreb University Hospital Center, Department of Pathology, Zagreb, Croatia

Abstract

Neuroendocrine tumors (NET) of the larynx are rare and heterogenous group, with much confusion about nature and
classification of these neoplasms in the past. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry
and electron microscopy. A classification in 4 different types; paraganglioma, typical carcinoid, atypical carcinoid and small cell neuroendocrine carcinoma (SCNC) is a current consensus. Thorough diagnostic and a proper classification of neuroendocrine neoplasms are of paramount importance – prognosis and treatment differ significantly. We present two cases: 63-year old patient with SCNC of the larynx and a 53-year old patient with atypical carcinoid of the larynx. OctreoScan is useful tools for diagnostics and follow up of the patients and it is predictive for effectiveness of octreotide therapy.

Keywords

neuroendocrine tumors; laryngeal neoplasms; therapy

Hrčak ID:

96498

URI

https://hrcak.srce.hr/96498

Publication date:

2.1.2013.

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