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Biochemia Medica, Vol. 23 No. 1, 2013.

Review article

https://doi.org/10.11613/BM.2013.014

Hepatitis during respiratory syncytial virus infection – a case report

Branka Kristić Kirin ; Daily Hospital, Srebrnjak Children’s Hospital, Zagreb, Croatia
Renata Zrinski Topić orcid id orcid.org/0000-0002-3740-7854 ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children’s Hospital, Zagreb, Croatia
Slavica Dodig orcid id orcid.org/0000-0002-3419-5171 ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children’s Hospital, Zagreb, Croatia

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Abstract

Introduction: Respiratory syncytial virus (RSV) infection is the most common cause of hospitalization in infants and small children. The aim was to present a 13-months old boy diagnosed with acute airway infection, acute otitis media (AOM) and hepatitis during the RSV-infection.
Material and methods: Serum catalytic activities of alkaline phosphatase (ALP), aspartate aminotranspherase (AST), alanine aminotranspherase (ALT), gamma glutamyl transpherase (GGT), lactate dehydrogenase (LD), and concentrations of bilirubin were monitored during hospitalization and at control examination.
Results: The child had clinical signs and symptoms of respiratory failure, AOM, and laboratory findings of virus infection and liver disease. On admission, catalytic activities of enzymes were markedly increased, especially the activity of ALP (10333 U/L, i.e. 24-fold increase in comparison with the upper reference limit). The highest increased in AST (339 U/L, 4.5-fold), ALT (475 U/L, 10.3-fold) and LD (545 U/L, 1.5-fold) were registered on the 3rd day, and the highest increase in GGT (68 U/L, 3.1-fold) occurred on the 11th day. Seven weeks after discharge AST, ALT, GGT and LD decreased into reference range, and ALP remain mildly increased (478 U/L, 1.1 fold increase). RSV was confirmed in nasal lavage fluid.
Conclusion: Laboratory results in patient with RSV infection needs to be interpreted in the light of both, respiratory and extrapulmonary manifestations of the infection, respectively.

Keywords

child; hepatitis; hyperphosphatasemia; otitis media; respiratory syncytial virus

Hrčak ID:

97254

URI

https://hrcak.srce.hr/97254

Publication date:

15.2.2013.

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