Acta Pharmaceutica, Vol. 63 No. 2, 2013.
Short communication, Note
https://doi.org/10.2478/acph-2013-0016
Synthesis and potential antimicrobial studies on some Mannich bases carrying imidazole moiety
PRIYA VINEETHA FRANK
; Department of Chemistry, Canara Engineering College, Benjanapadavu, Mangalore-574219, Karnataka, India
MAHESHA MANJUNATHA POOJARY
; Department of Chemistry, Canara Engineering College, Benjanapadavu, Mangalore-574219, Karnataka, India
NARAL DAMODARA
; Department of Chemistry, Canara Engineering College, Benjanapadavu, Mangalore-574219, Karnataka, India
CHANDRASHEKHAR CHIKKANNA
; PG Department of Medicinal Chemistry, SDM College, Ujire-574240, Karnataka, India
Abstract
Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione (3) was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.
Keywords
imidazole derivatives; Mannich bases; oxadiazole; antibacterial activity; antifungal activity
Hrčak ID:
97700
URI
Publication date:
30.6.2013.
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