Short communication, Note

Micellar liquid chromatographic analysis of benzyl alcohol and benzaldehyde in injectable formulations

MOHAMED RIZK
FAWZIA IBRAHIM
MOHAMED HEFNAWY
JENNY JEEHAN NASR

Abstract

An accurate, sensitive and selective reversed-phase micellar liquid chromatographic method was developed for simultaneous determination of benzyl alcohol and benzaldehyde. This method was applied in different injectable formulations containing diclofenac, piroxicam. lincomycin and clindamycin. The method showed excellent linearity in the range of 10100 and 120 μg mL1 with the limit of detection (S/N = 3) 0.25 μg mL (2.3 × 106 mol L1) and 0.12 µg mL1 (1.13 × 106 mol L1) for benzyl alcohol and benzaldehyde, respectively. The suggested method was successfully applied for the analysis of the studied drugs in bulk with average recoveries of 100.1 ± 1.0% for benzyl alcohol and 100.4 ± 1.6% for benzaldehyde and to the determination of benzyl alcohol and benzaldehyde in injectable formulations with the respective average recoveries of 99.8 ± 0.3 and 100.0 ± 0.4%.

Keywords

micellar liquid chromatography; benzyl alcohol; benzaldehyde; injectable formulations

Hrčak ID:

9849

URI

https://hrcak.srce.hr/9849

Publication date:

1.6.2007.

Article data in other languages: croatian

Visits: 3.815 *