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Collegium antropologicum, Vol. 37 No. 1, 2013.

Original scientific paper

Etiology and Epidemiology of Obstructive Jaundice in Continental Croatia

Ana Gudelj Gracanin ; University of Zagreb, Dubrava University Hospital, Department of Clinical Immunology and Rheumatology, Zagreb, Croatia
Milan Kujundzic ; University of Zagreb, Dubrava University Hospital, Department of Gastroenterology, Zagreb, Croatia
Mladen Petrovecki ; University of Zagreb, Dubrava University Hospital, Department of Laboratory Diagnostics, Zagreb, Croatia
Dario Rahelic ; University of Zagreb, Dubrava University Hospital, Department of Endocrynology, Zagreb, Croatia

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Abstract

The etiology and epidemiology of obstructive jaundice in Continental Croatia has been studied in 174 patients. The objective of this research was also to explore the importance and efficiency of endoscopic retrograde cholangiopancreatography (ERCP) as a non-surgical method of treatment of obstructive jaundice in the population of Continental Croatia. Obstructive jaundice is the illness of elderly population which is also confirmed by the information on the average age of our patients. The frequency of illness is higher among female population, and the most frequent cause of obstructive jaundice are gallstones (54.1% of patients). In 29.8% of patients the primary or secondary malignant disease was the cause of blockage in gall flow and subsequent jaundice, and the most frequent malignant cause of obstructive jaundice is pancreas cancer in 11.5% of patients. The mean value of serum concentrations of total bilirubin, alkaline phosphatase,
aspartate aminotransferase, alanine aminotransferase and gamma glutamiltransferase 24 hours before the biliary decompression
by ERCP has been significantly above the upper referential value, and 24 hours after the ERCP it has dropped to normal with their statistically significant difference (p<0.0001). The normal values of markers for synthetic liver function (total proteins and prothrombin time) have been noticed as well as elevated values of inflammatory markers
in obstructive jaundice independently of etiology. Out of the total number of patients, 37.7% required the surgical treatment while 60.3% of patients were treated by ERCP, i.e. either the stone extraction or the implantation of endobiliary stent was performed.

Keywords

etiology; epidemiology; obstructive jaundice; Continental Croatia; liver damage; ERCP

Hrčak ID:

99532

URI

https://hrcak.srce.hr/99532

Publication date:

3.4.2013.

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