Original scientific paper

Gizzerosine induced histopathological changes in laying hens.

Branka Artuković ; Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Željko Grabarević ; Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marina Tišljar ; Poultry Center, Croatian Veterinary Institute, Zagreb, Croatia
Andrea Gudan ; Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Mirna Robić ; Department of Pathophysiology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Petar Džaja ; Department of Forensic Veterinary Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Nada Granić ; Veterinary Station Dr. Milan Kralj, Metković, Croatia

Abstract

Histopathological changes in organs of laying hens challenged with different doses of gizzerosine (2.5; 5; 7.5 and 10 mg/kg b.w. daily during a three-week period) are described. The experiment was performed on 115 hens divided into five groups (K0/n=10/-no treatment, K1/n=21/-treatment with saline, G1/n=21/-2.5 mg/kg b.w. of gizzerosine, G2/n=21/-5 mg/kg b.w., G3/n=21/-7.5 mg/kg b.w.). Gross changes were mainly noticed on gizzards with mild congestion and reversible degenerative changes of the liver and kidneys. Among the histopathological changes (heart, liver, kidney, spleen, lungs, pancreas, brain, duodenum, and proventiculus) in the challenged groups the most prominent were blood vessel lesions (thickening and hyalinisation of the blood vessel walls, perivascular oedema and mononuclear parietal infiltration) especially in the lungs, brain and spleen. Parenchymatous, as well as hydropic and vacuolar degeneration due to hypoxia, were found in all examined tissues. The most prominent changes were in duodenum, where severe inflammation with necrosis was noted, while milder forms were characterized by the vacuolization of duodenal lamina propria. Pancreatic necroses were probably the consequence of direct toxicity of gizzerosine.

Keywords

laying hens; gizzerosine, histopathological lesions; subchronic changes

Hrčak ID:

66957

URI

https://hrcak.srce.hr/66957

Publication date:

20.2.2005.

Article data in other languages: croatian

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