Essays

Interplay between ubiquitin networks and NF-KB signaling

JANOŠ TERZIĆ ; Department of Immunology and Medical Genetics, University of Split, School of Medicine, Šoltanska 2, 21 000 Split, Croatia
IVAN ĐIKIĆ ; 1_Department of Immunology and Medical Genetics, University of Split, School of Medicine, Šoltanska 2, 21 000 Split, Croatia; 2_Frankfurt Institute for Molecular Life, Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodo

Abstract

NF-kB transcription factors were discovered 25 years ago and since then they have been in the focus of biomedical research. Their important role in immune system development is recognized and NF-kB is becoming more attractive because of its role in cancer biology. Understanding the molecular mechanisms controlling NF-kB activity appear important as possible therapeutic targets of numerous human diseases. Here we summarize how ubiquitin networks control the NF-kB pathway and specifically focus on recent findings implicating linear ubiquitin chains as critical components in this process.

Keywords

ubiquitin; NF-kB

Hrčak ID:

67227

URI

https://hrcak.srce.hr/67227

Publication date:

31.3.2011.

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