Short communication, Note

Interleukin-17 in experimental Klebsiella sepsis

VANJA VASILJEV MARCHESI orcid.org/0000-0002-4308-3008 ; Department of Social Medicine and Epidemiology, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51 000 Rijeka, Croatia
TOMISLAV RUKAVINA ; 1_Department of Social Medicine and Epidemiology, School of Medicine, University of Rijeka, Braće Branchetta 20, HR-51 000 Rijeka, Croatia; 2_Department of Microbiology, Teaching Institute of Public Health, Krešimirova 52a, HR-51 000 Rijeka, Croatia

Abstract

Background and Purpose: Interleukin-17 (IL-17) is a cytokine that
was described to be important in pathogenesis of several inflammatory conditions. Literature data suggest that modulation of IL-17 production or its biological effects may be beneficial in order to control the level of inflammation. However, data regarding its possible role in the pathogenesis of systemic infections are sparse.
Materials and Methods: Therefore, we decided to examine the kinetics
of systemic IL-17 production in our model of experimental murine Klebsiella sepsis.We also examined IL-17 production in mice treated with anti--lipopolysaccharide (anti-LPS) antibody prior to infection in order to see whether this pre-treatment, that was previously shown to significantly enhance the survival, is associated with changes in IL-17 production pattern.

Results: Our results show that experimental Klebsiella sepsis is associated with an increased systemic IL-17 production. The increase in production is much greater in saline pre-treated group compared with anti-LPS pre-treated animals.

Conclusions: We concluded that high levels of IL-17 in the blood may
contribute the mortality in mice with systemic Klebsiella infection.We also concluded that diminished IL-17 production in anti-LPS pre-treated animals is, at least partially, responsible for greater survival in this group.

Keywords

Hrčak ID:

67272

URI

https://hrcak.srce.hr/67272

Publication date:

31.3.2011.

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