Professional paper

Paget’s Disease of the Bone: a Clinical Report

Rashmi Venkatesh ; K.M.Shah Dental College & Hospital, Vadodara, India
Revan Kumar Joshi ; KGF College of dental science, Karnatka, India
Sushmini Ballal ; Oxford dental college and hospital, Bangalore, India

Abstract

Paget’s disease of bone (PDB) is a chronic bone remodeling disorder characterized by increased osteoclast-mediated bone resorption with subsequent new bone formation resulting in a disorganized mosaic of woven and lamellar bone at affected skeletal sites. The disease is usually not clinically apparent under 40 years of age. The clinical manifestations may range from asymptomatic to painful deformity of more than one bone. PDB is most common in white people of European descent, but it also occurs in black population, whereas it is rare in people of Asian descent. With anti-osteoclast therapy such as calcitonin and bisphosphonates many of the symptoms are relieved.
But the risk of future complications still remains. Unfortunately, very little evidence of long-term results is available. We report a case of Paget’s disease of bone with a brief review of literature.

Keywords

Osteitis Deformans; Bone Remodeling; Bone Resorption; Hypercementosis; Osteoclasts; Calcitonin; Diphosphonates

Hrčak ID:

69086

URI

https://hrcak.srce.hr/69086

Publication date:

15.6.2011.

Article data in other languages: croatian

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