Short communication, Note

https://doi.org/10.2478/v10007-011-0030-6

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

SONIAMOL JOSEPH ; Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram-695562
BABY SABULAL orcid.org/0000-0002-4337-9431 ; Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram-695562
VARUGHESE GEORGE ; Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram-695562
KUTTIKKADAN RONY ANTONY ; Amala Cancer Research Centre, Amala Nagar, Thrissur-680555
KAINOOR KRISHNANKUTTY JANARDHANAN ; Amala Cancer Research Centre, Amala Nagar, Thrissur-680555

Abstract

In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich’s ascites carcinoma cells. GLP at 100 mg kg–1 body mass showed 80.8 and 77.6 % reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2 % inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg–1, GLP exhibited 57.6 and 58.2 % inhibition in carrageenean-induced and formalin-induced assays, respectively.

Keywords

Ganoderma lucidum (Polyporaceae); polysaccharides; anti-inflammatory; antitumor activity

Hrčak ID:

69439

URI

https://hrcak.srce.hr/69439

Publication date:

1.9.2011.

Article data in other languages: croatian

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