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Biochemia Medica, Vol. 21 No. 2, 2011.

Original scientific paper

Urates in exhaled breath condensate of children with obstructive sleep apnea

Vukmir Vlasic ; Women’s & Children’s Hospital, Pediatric Pulmonology, Lafayette, LA, USA
Jasenka Trifunovic ; Clinical Hospital Center Osijek, Department of Clinical Biochemistry, Osijek, Croatia
Ivana Cepelak ; Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Hematology, University of Zagreb, Zagreb, Croatia
Petra Nimac ; Srebrnjak Children’s Hospital, Pediatric Department, Zagreb, Croatia
Renata Zrinski Topic ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children’s Hospital, Zagreb, Croatia
Slavica Dodig orcid id orcid.org/0000-0002-3419-5171 ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children’s Hospital, Zagreb, Croatia

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Abstract

Background: Urate levels may be a marker of oxidative stress. The aim of the present study was to find out are there any differences in urate concentrations in exhaled breath condensate (EBC) between children with obstructive sleep apnea (OSA) and healthy children.
Materials and methods: EBC was collected in children with obstructive sleep apnea (OSA) and clinically healthy children. Urate measurements in EBC and serum were performed by enzymatic co-lor test.
Results: The higher concentration of urates in EBC of children with OSA than clinically healthy chil-dren indicate the oxidative stress in their airways. Since there was no significant difference in serum concentration of urates between children with OSA and healthy children, it could be considered that urates are sintetized in the airways of children with OSA.
Conclusions: The present study indicated that urates in EBC (but not in serum) may be used as a marker of local synthesis of antioxidant compounds, but definitive conclusion must be supported by investigations involving larger number of participants.

Keywords

exhaled breath condensate; obstructive sleep apnea; oxidative stress; urates

Hrčak ID:

69657

URI

https://hrcak.srce.hr/69657

Publication date:

15.6.2011.

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