Biochemia Medica, Vol. 21 No. 2, 2011.
Original scientific paper
Identifying candidate genes for Parkinson’s disease by integrative genomics method
Amela Karic
; Department of Genetics, Faculty of Science, University of Tuzla, Tuzla, Bosnia and Herzegovina
Rifet Terzic
; Department of Genetics, Faculty of Science, University of Tuzla, Tuzla, Bosnia and Herzegovina
Alen Karic
; Clinics for Cardiovascular Diseases, University Medical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Borut Peterlin
; Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia
Abstract
Introduction: The recent studies of Parkinson’s disease (PD) indicate that genetics and environmen-tal factors may play an important role in developing of PD. Nowadays, the cell death and cell adhesi-on are pathogenetic mechanisms which could be related with PD. On the basis of relationship of tho-se mechanisms with PD, the aim of this study was to identify new candidate genes for PD by integra-tion of results of transcriptomics studies and results obtained by Biomedical Discovery Support System (BITOLA).
Materials and methods: For the detection of functional relationship between potential candidate ge-ne and pathogenetic mechanisms associated with PD, we designed strategy of integration of results of transcriptomics studies with discovery approach in bibliographic data bases and BITOLA. Data of chromosome location, tissue-specific expression, function of potential candidate genes and their as-sociation with genetics disorders were obtained from Medline, Locus Link, Gene Cards and OMIM.
Results: Integration and comparison of results obtained using the BITOLA system and analysis of transcriptomics studies identified six genes (MAPT, UCHL1, NSF, CDC42, PARK2 and GFPT1) that occur simultaneously in both group of results. The function of genes NSF, CDC42 and GFPT1 in the pathogenesis of PD has not been studied yet.
Conclusions: According to our result that aforementioned genes appeared in both groups of results and partially match the criteria set for the selection of candidate genes and their potential role in the development of PD, they should be tested by methods specifically intended for those three genes.
Keywords
Parkinson’s disease; candidate genes; Biomedical Discovery Support System (BITOLA)
Hrčak ID:
69666
URI
Publication date:
15.6.2011.
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