Original scientific paper

https://doi.org/10.5562/cca1751

Effects of n–3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats

Tamara Popović ; Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11000 Belgrade, Serbia
Sunčica Borozan ; Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 Belgrade, Serbia
Aleksandra Arsić ; Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11000 Belgrade, Serbia
Jasmina Debeljak-Martačić ; Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11000 Belgrade, Serbia
Vesna Vučić ; Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11000 Belgrade, Serbia
Silvio de Luka ; Institute for Pathological Physiology, Faculty of Medicine, Dr. Subotića 8, 11000 Belgrade, Serbia
Ivan Milovanović ; Institute for Pathological Physiology, Faculty of Medicine, Dr. Subotića 8, 11000 Belgrade, Serbia
Aleksandar Trbović ; Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11000 Belgrade, Serbia
Maria Glibetić ; Institute for Medical Research, University of Belgrade, Tadeusa Koscuska 1, 11000 Belgrade, Serbia

Abstract

The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine,
metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs)
status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and
liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins
(HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL
ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated
group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-.
linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic
acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic
acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared
to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased
while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest
that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing
risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)

Keywords

fish oil; aged rats; fatty acids; lipid status

Hrčak ID:

69697

URI

https://hrcak.srce.hr/69697

Publication date:

30.5.2011.

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