Croatica Chemica Acta, Vol. 84 No. 1, 2011.
Original scientific paper
https://doi.org/10.5562/cca1639
Simultaneous Effect of Organic Modifier and Physicochemical Parameters of Barbiturates on their Retention on a Narrow-Bore PGC Column. Part 2
Tibor Cserháti
; Research Institute of Materials and Environmental Chemistry, Chemical Research Centre, Hungarian Academy of Sciences, P.O. Box 17, 1525 Budapest, Hungary
Maria Szőgyi
; Research Institute of Materials and Environmental Chemistry, Chemical Research Centre, Hungarian Academy of Sciences, P.O. Box 17, 1525 Budapest, Hungary
Abstract
The retention time of 23 barbituric acid derivatives was determined on an narrow-bore porous graphitized carbon (PGC) column employing water-dioxane mixtures as mobile phases. The retention fac-tor (k), theoretical plate number (N), and asymmetry factor (AF) were computed for each analyte in each mobile phase. Quantitative structure-retention relationship (QSRR) calculations using stepwise regression analysis (SRA) demonstrated the binding of analytes to the surface of PGC stationary phase is influenced by electrostatic interaction and sterical correspondence between the stationary phase and the various sub-structures of barbituric acid derivatives. (doi: 10.5562/cca1639)
Keywords
barbiturates; porous graphitized carbon; quantitative structure-retention relationship
Hrčak ID:
69712
URI
Publication date:
30.5.2011.
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