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Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, Vol. 19 No. 3, 2010.

Original scientific paper

MIXED HPV INFECTION IS A POOR PROGNOSTIC FACTOR FOR SURVELANCE OF PATIENT WITH INVASIVE CERVICAL CANCER

Joško Lešin ; Klinika za ženske bolesti i porode KBC-a Zagreb, Petrova 13, Zagreb
Damir Babić ; Zavod za ginekološku patologiju KBC-a Zagreb, Zagreb
Jadranka Forko-Ilić ; Zavod za ginekološku patologiju KBC-a Zagreb, Zagreb
Mihael Skerlev ; Klinika za kožne i spolne bolesti KBC-a Zagreb
Joško Zekan ; Klinika za ženske bolesti i porode KBC-a Zagreb, Petrova 13, Zagreb
Miljenko Lugonja ; Sveučilišna klinička bolnica Mostar
Tomislav Župić ; Klinika za ženske bolesti i porode KBC-a Zagreb, Petrova 13, Zagreb

Full text: croatian pdf 174 Kb

page 141-147

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Abstract

Invasive cervical carcinoma is the fourth of all neoplasms of female genital reproductive system and 14/
100 000 women would got ill in Croatia during a year. Material and method. 120 patients with cervical carcinoma clinical stage IB-IIB treated in Department of Obstetrics and Gynecology Medical School University of Zagreb, were examined prospectivly during period 1996–2002. The aim of the study was to detect the HPV-type using PCR and Inno Lippa method and compare their significance as prognostic factors. Results. 102 patients left for the analysis, an average age was 51.38±14.04 (26–83). During the folow up of 5–98 months 23 (22.5%) patients died from cervical carcinoma. HPV type 16 infection (p=0.0008) and mixed HPV infection (p=0.0134) are connected with poor surviving. Using Cox regression model we analysed all the significant factors by univariate method and formed a model of high prediction for poor surviving (2=74.222, df=7, p<0.0001). HPV mixed infection (p=0.007) is independent predictive factors for poor surviving in patients with cervical carcinoma. Conclusion. HPV detection in patients with cervical carcinoma is necessary because mixed HPV infection is a poor prognostic factor for surveillance of patient with invasive cervical cancer.

Keywords

invasive cervical cancer; HPV type; Inno Lippa method; mixed HPV infection

Hrčak ID:

69734

URI

https://hrcak.srce.hr/69734

Publication date:

1.9.2010.

Article data in other languages: croatian

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