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Medica Jadertina, Vol. 41 No. 1-2, 2011.

Professional paper

The impact of Helicobacter pylori infection on C-reactive protein value in patients with stable coronary artery disease

Mia Ćićerić ; KBC Split, Klinika za unutarnje bolesti
Damir Fabijanić orcid id orcid.org/0000-0002-4199-3905 ; KBC Split, Klinika za unutarnje bolesti
Marko Banić ; KBC Split, Klinika za unutarnje bolesti
Duško Kardum ; KBC Split, Klinika za unutarnje bolesti
Dražen Zekanović ; Opća bolnica Zadar, Interni odjel
Damir Bonacin ; KBC Split, Klinika za unutarnje bolesti
Tina Bečić ; Medicinski fakultet Sveučilišta u Splitu, studentica medicine

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Abstract

Aim: Previous studies have shown the possible role of H. pylori infection in the development and progression of atherosclerosis. Increased values of proatherogenic C-reactive protein (CRP) due to the chronic inflammation are emphasized as one of the possible pathophysiological mechanisms. The aim of this study was to estimate the influence of H. pylori infection on the value of CRP in patients with stable coronary artery disease (CAD).
Patients and methods: The 100 patients with stable CAD confirmed by coronary angiography were enrolled in the study. Esophagogastroduodenoscopy was performed in all the included patients in order to determine H. pylori status. Serum hs-CRP value was estimated using high sensitivity essay (Cobas Integra
700, Roche, Mannheim, Germany) with detection range from 0.25 to 150 mg/L.
Results: 27 (27%) women (61.8 ± 10.3 y) and 73 (73%) men (63.9 ± 10.8 y) were enrolled in the study.
H. pylori infection was confirmed in 60 (60%) patients. There were no differences in laboratory, clinical and demographic parameters between H. pylori positive and H. pylori negative patients. Also, there were no differences in serum C-reactive protein values between these two groups of patients. The value of hs-CRP in H. pylori positive patients was 5.5 (0.6 – 21.2) mg/l regarding 4.8 (0.3 – 17.3) mg/l revealed in H. pylori negative patients (z = 1.225, p = 0.221).
Conclusion: The main observation of the presented study was that H. pylori infection does not affect the value of serum hs-CRP in patients with stable CAD.

Keywords

atherosclerosis; C-reactive protein; H. pylori; coronary artery disease

Hrčak ID:

70297

URI

https://hrcak.srce.hr/70297

Publication date:

6.7.2011.

Article data in other languages: croatian

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