Original scientific paper

Effect of E. coli endotoxin induced fever on the pharmacokinetic profile and dosage regimen of ceftriaxone in sheep (Ovis aries).

Rajeev Ranjan ; Department of Pharmacology and Toxicology, Ranchi College of Veterinary Science and Animal Husbandry, Birsa Agriculture University, Ranchi, Jharkhand, India
Birendra K. Roy ; Department of Pharmacology and Toxicology, Ranchi College of Veterinary Science and Animal Husbandry, Birsa Agriculture University, Ranchi, Jharkhand, India
Amita Ranjan ; Department of Pharmacology and Toxicology, Ranchi College of Veterinary Science and Animal Husbandry, Birsa Agriculture University, Ranchi, Jharkhand, India
Sanjeet K. Singh ; Department of Livestock Production and Management, Ranchi College of Veterinary Science and AnimalHusbandry, Birsa Agriculture University, Ranchi, Jharkhand, India

Abstract

The effect of fever was studied on the pharmacokinetics of ceftriaxone (CTRX) following intravenous administration at the rate of 50 mg/kg b.m. in Chhotanagpuri sheep. Fever was induced by intravenous administration of E. coli serovar O126:B8 lipopolysaccharide, and plasma CTRX concentration was estimated by HPLC. The plasma drug concentration versus time curve best fitted a two compartment open model. The maximum plasma drug concentration was 16.33 per cent lower in febrile sheep (FS) in comparison to normal sheep (NS). In FS, t1/2α was lower, while t1/2β was higher than in NS. Vdarea and P: C ratio was higher in FS, but ClB and AUC did not differ significantly between the two groups. The results of the present study indicate that CTRX has greater distribution in the peripheral compartment during pyrexia. High values of K12/K /K21 ratio also indicated rapid drug distribution in various body fluids and compartments. The suitable dosage regimen of CTRX in FS by the intravenous route was calculated to be 15 mg/kg b.m. at a 5 h interval.

Keywords

ceftriaxone; E. coli-endotoxin; pharmacokinetics; pyrexia; sheep

Hrčak ID:

70855

URI

https://hrcak.srce.hr/70855

Publication date:

20.7.2011.

Article data in other languages: croatian

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