Original scientific paper
Progress with a Multiscale Systems Engineering Approach to Cardiac Development
Ronald Summers
; Department of Electronic and Electrical Engineering, Loughborough University, Ashby Road, Loughborough, LE11 3TU, United Kingdom
Tariq Abdulla
; Department of Electronic and Electrical Engineering, Loughborough University, Ashby Road, Loughborough, LE11 3TU, United Kingdom
Lucile Houyel
; Department of Cardiology, Hospital Marie-Lannelongue, 133 avenue de la Resistance, 92350 Le Plessis-Robinson, Paris, France
Jean Marc Schleich
; Competence Centre for Congenital Heart Defects, Department of Cardiology and Vascular Medicine, Hospital Pontchaillou, 35033 Rennes CEDEX, France
Abstract
Multiscale systems engineering provides a way to integrate models of real-world phenomena that allows a holistic understanding of component interactions at different levels of scale simultaneously. The discipline draws upon information engineering to provide ontological representations that are derived from digital libraries of terms, them-selves found at distributed locations around the world. Cardiac development is well understood within discrete levels of analysis. The application of the multiscale framework gives added value by unlocking the relationships between genetic-based information at one level of analysis and the phenotype it encodes for at the cell and organ levels of abstraction. The multiscale-based relationships have begun to demonstrate new insights into normal cardiac development and conditions that give rise to congenital heart diseases such as the tetralogy of Fallot. This paper describes progress made in combining ontology-based information models and explains the importance of the role of multiscale systems engineering.
Keywords
Cardiac development; Information engineering; Multiscale; Ontology
Hrčak ID:
71269
URI
Publication date:
22.7.2011.
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