Short communication, Note

https://doi.org/10.2478/v10007-011-0034-2

Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives

SONI A. SINGH ; Advanced Research Laboratory in Synthetic and Natural Product Chemistry, V. G. Vaze College, Mumbai University, Mulund (E), Mumbai 400 0081, India
SUJATA V. BHAT ; Advanced Research Laboratory in Synthetic and Natural Product Chemistry, V. G. Vaze College, Mumbai University, Mulund (E), Mumbai 400 0081, India

Abstract

Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.

Keywords

3-hydroxy-2-methylene-3-phenylpropionic acid derivatives; antibacterial activity; antifungal activity; Baylis-Hillman reaction

Hrčak ID:

71380

URI

https://hrcak.srce.hr/71380

Publication date:

31.12.2011.

Article data in other languages: croatian

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