Review article

https://doi.org/10.5562/cca1819

Cyclic Lipodepsipeptides in Novel Antimicrobial Drug Discovery

Nina Bionda ; Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA
Predrag Cudic ; Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA

Abstract

Naturally occurring cyclic depsipeptides, microbial secondary metabolites that contain one or
more ester bonds in addition to the amide bonds, have emerged as an important source of pharmacologically
active compounds or promising lead structures for the development of novel synthetically derived
drugs. In particular, their lipidated derivatives have shown the greatest therapeutic potential as antimicrobial
agents. Some of those compounds are either already marketed (daptomycin 37) or in advanced
stages of clinical development (ramoplanin 32) for the treatment of complicated infections caused by multidrug-
resistant bacterial strains. As bacteria progressively become resistant to frontline antimicrobial
agents, our capacity to effectively treat bacterial infections becomes severely hindered. Therefore, identifying
novel antibacterial targets and new antibacterial chemotherapeutics capable of treating infections
from drug-resistant microorganisms is of vital importance.(doi: 10.5562/cca1819)

Keywords

antibiotic; cyclic; lipodepsipeptide

Hrčak ID:

71994

URI

https://hrcak.srce.hr/71994

Publication date:

3.10.2011.

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