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Biomarkers of inflammation and cardiac remodeling: the quest of relevant companions for the risk stratification of heart failure patients is still ongoing

Damien Gruson ; Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium
Sylvie A. Ahn ; Division of Cardiology, Cliniques Universitaires St-Luc, Brussels, Belgium
Michel F. Rousseau ; Division of Cardiology, Cliniques Universitaires St-Luc, Brussels, Belgium

Abstract

Heart failure (HF) is a frequent chronic disease in elderly people and represents a major health and economic burden. The accurate diagnosis of HF and the identification of high risk patients is manda-tory to select the appropriate therapy and care. HF is associated to cardiac remodeling and inflamma-tion and to the release of neurohormones. If natriuretic peptides remain the biomarkers of choice for the diagnosis and the prognosis of HF, several biomarkers related to cardiac remodeling and inflammation are available for testing and may add valuable information for the risk estimation of HF pa-tients and for the selection of the most appropriated therapy. Furthermore, the quest for new efficient biomarkers of cardiac remodeling and inflammation is still ongoing and new candidates have been identified for a potential use in daily clinical practices. However, before their potential translation to routine parameters several challenges ranging form the analytical validation to the cost-effectiveness estimation should be considered.

Keywords

inflammation; remodeling; heart failure; prognosis; biomarkers

Hrčak ID:

72946

URI

https://hrcak.srce.hr/72946

Publication date:

15.10.2011.

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